Preheat your oven to 425°F and line a large baking sheet with parchment paper.
Pat the shrimp thoroughly dry with paper towels and place them in a medium bowl.
In a separate small bowl, combine the panko breadcrumbs, melted butter (or oil), garlic powder, onion powder, paprika, salt, and pepper. Stir until the crumbs are evenly moistened.
Toss the shrimp with a teaspoon of oil to help the coating stick.
One by one, press each shrimp firmly into the panko mixture until well-coated on both sides.
Place the shrimp on the prepared baking sheet in a single layer.
Bake for 8–10 minutes, or until the shrimp are opaque and the breadcrumbs are golden brown.
Garnish with fresh parsley and serve immediately with fresh lemon wedges.